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Improvement from baseline in the individual components of the ACR responder criteria was also sustained in most patients during the second year of Arava treatment in all three trials.
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As the study did not succeed at demonstrating the superiority of the add-on versus the switch strategy, we discuss here factors that could potentially have biased the study outcome, before rejecting the clinical study hypothesis.
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Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J: Harrisons Principles of Internal Medicine, 19e: 2015.
This feature is critical to its pharmacological effects because a typical anti-IgE antibody can cross-link cell surface FcεRI-bound IgE, thereby aggregate FcεRI, and activate mast cells and basophils to discharge the horde of chemical mediators stored in the densely packed sacs inside the cells.
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Los participantes del estudio fueron voluntarios en la investigacin o ya iban a someterse al procedimiento para diagnosticar un problema digestivo.
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